Diadenosine tetraphosphate contributes to carbachol-induced tear secretion
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چکیده
منابع مشابه
Analogs of diadenosine tetraphosphate (Ap4A).
This review summarizes our knowledge of analogs and derivatives of diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A), the most extensively studied member of the dinucleoside 5',5"'-P1,Pn-polyphosphate (NpnN) family. After a short discussion of enzymes that may be responsible for the accumulation and degradation of Np4)N's in the cell, this review focuses on chemically and/or enzymatically produced...
متن کاملEndogenous diadenosine tetraphosphate, diadenosine pentaphosphate, and diadenosine hexaphosphate in human myocardial tissue.
Diadenosine polyphosphates have been characterized as extracellular mediators controlling numerous physiological effects. In this study, diadenosine tetraphosphate, diadenosine pentaphosphate, and diadenosine hexaphosphate were isolated and identified in human myocardial tissue. Human myocardial tissue was homogenized and fractionated by affinity chromatography, displacement chromatography, ani...
متن کاملDiadenosine Tetraphosphate Hydrolase from Mouse Liver
An enzyme hydrolyzing diadenosine 5’,5”’-P1,P4-tetraphosphate (Ap4A) to AMP and ATP has been purified to apparent homogeneity from mouse liver cell extracts. The isolation procedure comprised ammonium sulfate precipitation, chromatography on Sephadex G75, DEAEhellulose, blue Sepharose and AMP-Sepharose. The enzyme is a single polypeptide chain with a native M, = 64,000 with a K,,, of 1.66 PM an...
متن کاملStructural and functional attributes of malaria parasite diadenosine tetraphosphate hydrolase.
Malaria symptoms are driven by periodic multiplication cycles of Plasmodium parasites in human red blood corpuscles (RBCs). Malaria infection still accounts for ~600,000 annual deaths, and hence discovery of both new drug targets and drugs remains vital. In the present study, we have investigated the malaria parasite enzyme diadenosine tetraphosphate (Ap4A) hydrolase that regulates levels of si...
متن کاملDiadenosine tetraphosphate-gating of recombinant pancreatic ATP-sensitive K(+) channels.
Diadenosine tetraphosphate (Ap4A) has been recently discovered in the pancreatic beta cells where targets ATP-sensitive K(+) (K(ATP)) channels, depolarizes the cell membrane and induces insulin secretion. However, whether Ap4A inhibit pancreatic K(ATP) channels by targeting protein channel complex itself was unknown. Therefore, we coexpressed pancreatic K(ATP) channel subunits, Kir6.2 and SUR1,...
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ژورنال
عنوان ژورنال: Purinergic Signalling
سال: 2014
ISSN: 1573-9538,1573-9546
DOI: 10.1007/s11302-014-9434-3